Drayton Hall is an 18th-century plantation located on the Ashley River about 15 miles northwest of Charleston, South Carolina, and directly across the Ashley River from North Charleston, west of the Ashley in the Lowcountry. An outstanding example of Palladian architecture in North America and the only plantation house on the Ashley River to survive intact through both the Revolutionary and Civil wars, it is a National Historic Landmark.

And here’s a little more from the Drayton Hall foundation website:

For more than 250 years, Drayton Hall has stood witness to the American South. Among the best and most complete examples of Southern colonial life open to the public today, the property holds a vital educational responsibility. It is also an active archaeological site with an extensive museum collection of rare 18th- and 19th-century objects and artifacts.

As far as South Carolina plantation tours go, this one is pretty decent.